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Curriculum vitae
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Name:Anders Malmendal
Profession:Associate Professor
Email:anders@chem.au.dk
Homepage:None
Work address: Laboratory for Biomolecular NMR Spectroscopy
Department of Chemistry
University of Aarhus
Langelandsgade 140, DK-8000 Aarhus C, Denmark
Home address: Kaserneboulevarden 15 1. th
DK-8000 Aarhus C
Denmark
Office: Room 511-224
Office phone: +45 8942 3857
Dept. duties:

Research

NMR as a tool in complex biological systems. Development and application of NMR spectroscopy to metabolomic studies, and to the study of molecular structure and dynamics in chemistry, molecular biology, and nanotechnology. Exploration of metabolomic responses of a wide variety of systems. Determination of high-resolution three-dimensional structures and dynamics on various timescales for biological macromolecules, drugs, organic compounds using liquid- and solid-state NMR, with focus on insoluble systems such as fibrillating proteins, membrane proteins. Major areas include coupling of metabolomic responses to different stimuli and other omic responses; coupling of protein dynamics and structure and their response to interactions with ions, other proteins, membranes, etc, with a special focus on protein folding and misfolding.
 

Curriculum Vitae


Personal data

Name:Anders Malmendal
Nationality:Swedish
Date of Birth:January 13, 1967


Education

1993:M. Sc., Chemical Engineering, Lund University and ENSIGC Toulouse
1999:Ph. D., Physical Chemistry, Lund University


Appointments

1993 - 1999:Ph.D. training position, Physical Chemistry 2, Lund University, Lund, Sweden
1999:STINT (The Swedish Foundation for International Cooperation in Research and Higher Education) postdoctoral fellow, Dept. Mol. Biol. & Dept. Cell. Biol., Scripps Research Institute, La Jolla, CA, USA
1999 - 2001:STINT postdoctoral fellow, Dept. Biochem., Vanderbilt University Medical Center, Nashville, TN, USA
2001 - 2005:Research Assistant Professor, Laboratory for Biomolecular NMR Spectroscopy, Dept. Mol. Biol. & Dept. Chem., University of Aarhus, Aarhus, Denmark
2005 -:Research Associate Professor, Laboratory for Biomolecular NMR Spectroscopy, Dept. Chem., University of Aarhus, Aarhus, Denmark

Publications

Publications in Reviewed Journals

  1. J. F. Young, L. B. Larsen, A. Malmendal, N. C. Nielsen, I. K. Straadt, N. Oksbjerg, and H. C. Bertram, Journal of the International Society of Sports Nutrition , (In press).
    Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics
  2. M. Bayley, J. Overgaard, A. S. Høj, A. Malmendal, N. C. Nielsen, M. Holmstrup, and T. Wang, Phys. Biochem. Zool , (In press).
    Metabonomic Changes During Aestivation in the Common Earthworm Aporrectodea caliginosa
  3. H. C. Bertram, A. Malmendal, N. C. Nielsen, I. K. Straadt, T. Larsen, K. E. B. Knudsen, and H. N. Lærke, Mol. Nutrition Food Res 53, 1055-1062 (2009).
    NMR-based metabonomics reveals that betaine plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolaemic pigs
  4. H. C. Bertram, N. B. Kristensen, M. Vestergaard, S. K. Jensen, J. Sehested, N. C. Nielsen, and A. Malmendal, Livestock Science 120, 127-134 (2009).
    Metabolic Characterization of Rumen Epithelial Tissue from Dairy Calves Fed Different Starter Diets using 1H NMR Spectroscopy
  5. R. Halaban, M. Krauthammer, M. Pelizzola, E. Cheng, D. Kovacs, M. Sznol, S. Ariyan, D. Narayan, A. Bacchiocchi, A. Molinaro, Y. Kluger, M. Deng, N. Tran, W. Zhang, M. Picardo, and J. J. Enghild, PLoS ONE 4, e4563 (2009).
    Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications
  6. S. Slotsbo, K. Maraldo, A. Malmendal, N. C. Nielsen, and M. Holmstrup, Cryobiology 57, 286-291 (2008).
    Freeze-tolerance and accumulation of cryoprotectants in the enchytraied Enchytraeus albidus (Oligochaeta) from Greenland and Europe
  7. K. E. Nielsen, J. Dittmer, A. Malmendal, and N. C. Nielsen, Energy & Fuels 22, 4070-4076 (2008).
    Quantitative analysis of constituents in heavy fuel oil by 1H Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate data analysis
  8. K. S. Pedersen, T. N. Kristensen, V. Loeschcke, B. O. Pedersen, J. Ø. Duus, N. C. Nielsen and A. Malmendal, Genetics 180, 1233-1243 (2008).
  9. J. Overgaard, A. Malmendal, J. G. S?rensen, J. G. Bundy, V. Loeschcke, N. C. Nielsen, and M. Holmstrup, J. Insect Physiol 53, 1218-1232 (2007).
    Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogaster
  10. J. F. Young, H. C. Bertram, P. K. Theil, A.-G. D. Petersen, K. A. Poulsen, M. Rasmussen, A. Malmendal, N. C. Nielsen, M. Vestergaard, and N. Oksbjerg, Meat Science 76, 342-351 (2007).
    In vitro and in vivo studies of creatine monohydrate supplementation to Duroc and Landrace pigs
  11. J. K. Jensen, A. Malmendal, B. Schi?tt, S. Skeldal, K. E. Petersen, L. Celik, N. C. Nielsen, P. A. Andreasen, and T. Wind, Biochemical Journal 399, 387-396 (2006).
    Inhibition of Plasminogen Activator Inhibitor-1 Binding to Endocytosis Receptors of the low Density Lipoprotein Receptor Family by a Peptide Isolated from a Phage Displayed Library
  12. J. Underhaug, L. Odgaard Jakobsen, A. Malmendal, P. Fojan, M. Esmann, and N. C. Nielsen, FEBS Lett. 580, 4777-4783 (2006).
    NMR studies of the Fifth Transmembrane Segment of Na+,K+-ATPase Reveals a Non-Helical Ion-Binding Region
  13. A. Malmendal, J. Overgaard, J. G. Bundy, J. G. S?rensen, N. C. Nielsen, V. Loeschcke, M. Holmstrup, American Journal of Physiology 291, 205-212 (2006).
    Metabolomic Profiling of Heat Stress: Hardening and Recovery of Homeostasis in Drosophila
  14. H.C. Bertram, K.E.B. Knudsen, A. Serana, A. Malmendal, N.C. Nielsen, X.C. Frett? and H.J. Andersen, British J. Nutrition 5, 955-962 (2006).
    NMR-based Metabonomic Studies Reveal Changes in the Biochemical Profile of Plasma and Urine from Pigs Fed High Fiber a Rye Bread
  15. H. C. Bertram, N. B. Kristensen, A. Malmendal, N. C. Nielsen, R. Bro, H. J. Andersen, and D. L. Harmon, Analytica Chimica Acta 536, 1-6 (2005).
    A metabolomic investigation of splanchnic metabolism using 1H NMR spectroscopy of bovine blood plasma
  16. A. Malmendal, C. W. Vander Kooi, N. C. Nielsen, and W. Chazin, Biochemistry 44, 6502-6512 (2005).
    Calcium-modulated S100 protein-phospholipic interactions. An NMR study of calbindin D9k and DPC
  17. N.C. Nielsen, A. Malmendal, and T. Vosegaard, Mol. Membr. Biol. 21, 129-141 (2004).
    Techniques and Applications of NMR to Membrane Proteins
  18. H.C. Bertram, N.B. Kristensen, A. Malmendal, N.C. Nielsen, S.K. Jensen, and D.L. Harnon, J. Anum Feed. Sci. , 295-298 (2004).
    An NMR-based metabolomic approach to assess metabolism in splanchnic tissues of steers
  19. J. Christodoulou, A. Malmendal, J.F. Harper, W.J. Chazin., J. Biol. Chem. 279, 29092-29100 (2004).
    Evidence for differing roles for each lobe of the Calmodulin-like domain in a calcium-dependent protein kinase (CDPK)
  20. M. Bjerring, T. Vosegaard, A. Malmendal, and N. C. Nielsen, Concepts Magn. Reson. 18A, 111-129 (2003).
    Methodological Development of Solid-State NMR for Characterization of Membrane Proteins
  21. G. Nielsen, A. Malmendal, A. Meissner, J. Vuust Møller, and N. C. Nielsen, FEBS Lett. 544, 50-56 (2003).
    NMR studies of the fifth transmembrane segment of sarcoplasmic reticulum Ca2+-ATPase reveals a hinge close to the Ca2+ ligating residues
  22. A. Malmendal, S. Halpain, and W. J. Chazin, Biochem. Biophys. Res. Comm. 301, 136-142 (2003).
    Nascent structure in the kinase anchoring domain of microtubule-associated protein 2.
  23. T. Vosegaard, A. Malmendal, and N. C. Nielsen, Chem. Monthly 133, 1555-1574 (2002).
    The Flexibility of SIMPSON and SIMMOL for Numerical Simulations in Solid and Liquid-State NMR Spectroscopy
  24. J. Evenäs, A. Malmendal, and M. Akke, Structure 9, 185-195 (2001).
    Dynamics of the Transition between Open and Closed Conformations in a Calmodulin C-Terminal Domain Mutant
  25. A. Malmendal, S. Linse, J. Evenäs, S. Forsén, and T. Drakenberg, Biochemistry 38, 11844-11850 (1999).
    Battle for the EF-Hands: Magnesium-Calcium Interference in Calmodulin
  26. J. Evenäs, S. Forsén, A. Malmendal, and M. Akke, J. Mol. Biol. 289, 603-617 (1999).
    Backbone Dynamics and Energetics of a Calmodulin Domain Mutant Exchanging between Closed and Open Conformations
  27. A. Malmendal, J. Evenäs, S. Fors'en, and M. Akke, J. Mol. Biol. 293, 883-899 (1999).
    Structural Dynamics in the C-terminal Domain of Calmodulin at Low Calcium Levels
  28. A. Malmendal, G. Carlström, C. Hambraeus, T. Drakenberg, S. Forsén, and M. Akke, Biochemistry 37, 2586-2595 (1998).
    Sequence and Context Dependence of EF-Hand Loop Dynamics. An 15N Relaxation Study of a Calcium-Binding Site Mutant of Calbindin D9k
  29. J. Evenäs, A. Malmendal, and S. Forsén, Curr. Opin. Chem. Biol. 2, 293-302 (1998).
    Calcium
  30. J. Evenäs, A. Malmendal, E. Thulin, G. Carlström, and S. Forsén, Biochemistry 37, 13744-13754 (1998).
    Ca2+ Binding and Conformational Changes in a Calmodulin Domain
  31. A. Malmendal, J. Evenäs, E. Thulin, G. P. Gippert, T. Drakenberg, and S. Forsén, J. Biol. Chem. 273, 28994-29001 (1998).
    When Size Is Important: Accomodation of magnesium in a calcium binding regulatory domain
  32. M. Andersson, A. Malmendal, S. Linse, I. Ivarsson, S. Forsén, and L. A. Svensson, Protein Sci. 6, 1139-1147 (1997).
    Structural basis for the negative allostery between Ca2+- and Mg2+-binding in the intracellular Ca2+-receptor calbindin D9k
  33. J. Evenäs, E. Thulin, A. Malmendal, S. Forsén, and G. Carlström, Biochemistry 36, 3448-3457 (1997).
    NMR Studies of the E140Q Mutant of the Carboxy-Terminal Domain of Calmodulin Reveal Global Conformational Exchange in the Ca2+-Saturated State
  34. D. Bentrop, I. Bertini, M. A. Cremonini, S. Forsén, C. Luchinat, and A. Malmendal, Biochemistry 36, 11605-11618 (1997).
    Solution Structure of the Paramagnetic Complex of the N-Terminal Domain of Calmodulin with Two Ce3+ Ions by 1H NMR
 
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Feb 8, 2008
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